Hungarian Molecular Life Science Conference 2021

5-7 November 2021 | Hotel Eger Park

Preliminary programme

Day 1 – Friday, 5 November 2021

14:00-14:10 Opening
14:10-15:20 Plenary session
Congress Hall

Chair: József Mihály
14:10-14:45 PL-1
Imre Kacskovics
Development of a recombinant ACE2-Fc fusion protein as a potential drug against SARS-CoV-2
14:45-15:20 PL-2
Beáta Lontay
New quarterback in the field of insulin resistance
15:20-15:45 Bioscience award talk
15:20-15:45 BA
Ádám Póti
Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents
15:45-16:15 Company talks
15:45-16:00 Zeiss
Chris Power (Carl Zeiss, Cambridge, United Kingdom)
Overview of recent advances in optical sectioning microcopy at Carl Zeiss
16:00-16:15 Kvalitex
Kristin Schnettler (BIOLABS, NEW ENGLAND)
How to build a streamlined, easy scalable and multi-functional DNA & RNA NGS Library prep pipeline
16:15-17:00 Coffee break
17:00-18:35 Molecular mechanism of diseases I.
Congress Hall

Chair: Zsuzsa Szondy
Protein structure & function
Room Liget I.

Chair: László Nyitray
17:00-17:20 O-01
Zsuzsanna Izsvak

PiggyBac Transposable Element-derived 1, unique to mammals, controls Neuronal Progenitor Identity, Stress Sensing and mammal-specific paraspeckles
O-07
Zoltán Lipinszki

Novel Perspectives of Target-binding by the Evolutionarily Conserved PP4 Phosphatase
17:20-17:35 O-02
András Szabó

Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis
O-08
Kinga Nyiri

Investigation of Protein and Peptide type Inhibitors of the Human dUTPase
17:35-17:50 O-03
Tamás Arányi

The pathogenic p.R391G ABCC6 displays incomplete penetrance implying the necessity of an interacting partner for the development of pseudoxanthoma elasticum
O-09
Zoltán Gáspári

Dynamic ensembles highlight unique features of the PDZ domains of PSD-95
17:50-18:05 O-04
Andrea Kelemen

IFITM1 expression determines extracellular vesicle uptake in colorectal cancer
O-10
Beáta Longauer

Effect of A22 and nucleotides on MreB polymerisation
18:05-18:20 O-05
Andrea Ciliberto

Epistasis, aneuploidy, and functional mutations underlie the evolution of resistance to induced microtubule depolymerization
O-11
Tamás Hegedűs

Transmembrane protein structure prediction by AlphaFold2
18:20-18:35 O-06
Zoltán Wiener

WNT Activity And Cell Proliferation are Coupled to Extracellular Vesicle Release in Lung Cancer Organoid Models
O-12
Ágnes Tantos

RNA binding of SETD1A and SETD1B
18:45-20:15 Welcome dinner
20:15-22:00 Poster discussion with drinks – ODD number posters
Jump to List of posters

Proteomics Clinique

 

Day 2 – Saturday, 6 November 2021

09:00-10:35 Molecular mechanism of diseases II.
Congress Hall

Chair: Gábor Szabó
Developmental Genetics
Room Liget I.

Chair: Rita Sinka
09:00-09:20 O-13
Bálint Bálint

Machine-learning based method to predict endometroid grade and relapse risk from global gene expression datasets
O-18
Gábor Csordás

Immune cell redirection reveals the underlying mechanisms of hematopoietic tissue formation in Drosophila
09:20-09:35 O-14
Éva Csősz

Amino acids and biogenic amines as indicators of altered metabolic fluxes in obesity and diabetes
O-19
Péter Borkúti

The biological significance of nuclear actin
09:35-09:50 O-15
Krisztina Tar

The diverse functions of the proteasome activator PA200 to maintain cellular quality control.
O-20
István Földi

Role of formin proteins in the cytoskeleton coordination during axonal growth
09:50-10:05 O-16
Endre Kristóf

Irisin stimulates the release of CXCL1 from human subcutaneous and deep-neck derived adipocytes
O-21
Elham Alzyoud

Microtubule organizing centers contain testis-specific γ-TuRC proteins in spermatids of Drosophila
10:05-10:20 O-17
Iván Uray

Dissecting drug interactions utilizing rexinoid and G-protein-coupled receptors for cancer prevention
O-22
Áron Szabó

LC3-associated Phagocytosis Promotes Glial Degradation of Axon Debris after Injury
10:20-11:05 Coffee break
11:05-12:40 Genome manipulation & archeogenetics
Congress Hall

Chair: Zoltán Ivics
Cell differentiation and signaling
Room Liget I.

Chair: László Buday
11:05-11:25 O-23
Zoltán Ivics

Engineered Sleeping Beauty Transposase Redirects Transposon Integration Away from Genes
O-29
Zsolt Sarang

Impaired Skeletal Muscle Development and Regeneration in Transglutaminase 2 Knockout Mice
11:25-11:40 O-24
András Tálas

BEAR reveals that increased fidelity variants can successfully reduce the mismatch-tolerance of adenine but not cytosine base editors
O-30
Erika Gábor

Elucidating the Regulation of Hemocyte Transdifferentiation with a Complex Deep Learning Based Technology In Drosophila Melanogaster
11:40-11:55 O-25
Péter István Kulcsár

How to choose the most suitable increased fidelity SpCas9 nuclease for high specificity genome editing
O-31
Milán Somogyvári

The sirtuin ortholog SIR-2.1 regulates lipolysis via the heat shock factor HSF-1 in C. elegans
11:55-12:10 O-26
Dániel Gerber

Genetic history and life of Bronze Age communities in Western Hungary
O-32
Anita Kurilla

Identification of oncogene-specific Tks4-Binding Protein Complexes as Biomarker Panels for Various Cancers
12:10-12:25 O-27
Bea Szeifert

Chapters from Carpathian Basin’s Early Medieval genetic history
O-33
Fadi Ramadan

Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16f10 Melanoma Cells
12:25-12:40 O-28
Tibor Török

Population Genoimc Characterization of Migration Period Populations in the Carpathian Basin
O-34
Károly Jambrovics

Role of transglutaminase 2 (TG2) in the differentiation and apoptotic processes of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) treated NB4 leukaemia cell lines
12:40-14:10 Lunch
14:10-15:20 Plenary session
Congress Hall

Chair: Mihály Kovács
14:10-14:45 PL-3
László Nagy
Evolution repeats itself in fungal morphogenetic transitions - in search of mechanisms of convergent evolution
14:45-15:20 PL-4
János Réthelyi
CRISPR genome editing based isogenic induced pluripotent stem cell system for modeling ZMYND11 de novo mutation in schizophrenia
15:20-15:35 Company talks
15:20-15:35 Biovendor


15:35-15:40 Technical break
15:40-16:45 Drug development
Congress Hall

Chair: László Virág
Stem cells
Room Liget I.

Chair: András Nagy
15:40-16:00 O-35
László Virág

High-Content Screening For Drug Development
O-39
András Nagy

Combining gene and cell therapy offers “universal” cells to treat disease
16:00-16:15 O-36
Csilla Laczka

Fluorescent probes of Organic Anion Transporting Polypeptides (OATPs), transporters involved in drug ADME-Tox
O-40
Kornélia Szebényi

Human ALS/FTD Brain Organoid Slice Cultures Display Distinct Early Astrocyte and Targetable Neuronal Pathology
16:15-16:30 O-37
Máté Lengyel

Targeting serotonergic signaling as a potential growth control pathway in breast cells
O-41
Tünde Szatmári

Ionizing radiation differentially affects the uptake of extracellular vesicles by bone marrow cell subpopulations
16:30-16:45 O-38
András Füredi

Switching off Drug Resistance in Cancer
O-42
István Szatmári

Zbtb46 dependent altered developmental program in embryonic stem cell derived blood cell progenitors: improved erythropoiesis and diminished myelopoiesis
16:45-19:00 Poster discussion with coffee break, EVEN number posters
Jump to Poster session

Proteomics Clinique
20:00- Banquet

 

Day 3 – Sunday, 7 November 2021

09:30-11:05 DNA repair and carcinogenesis
Congress Hall
Chair: Dávid Szüts
Session epigenetics & regulation of gene expression
Room Liget I.
Chair: Tamás Arányi
09:30-09:50 O-43
Mihály Kovács

Liquid-liquid phase separation driven by ssDNA binding protein enables rapid and efficient genome repair
O-49
Tibor Pankotai

Transcriptional changes in response to DNA damage
09:50-10:05 O-44
Péter Burkovics

The role of human WRNIP1 protein in genome maintenance
O-50
László Imre

Fundamental Role of The H2A.Z C-terminal Tail in The Formation of Constitutive Heterochromatin
10:05-10:20 O-45
Lóránt Székvölgyi

Chromatin architectural changes set the stage for meiotic DNA break formation
O-51
Ildikó Kristó

Moesin is involved in mRNA export as a new member of the Mediator complex
10:20-10:35 O-46
Éva Bálint

Functional significance of the Rad18 Zn-finger mediated interaction with Rad5
O-52
Maher Alnajjar

Combined RNA-seq and WGS analysis of a rabbit family reveals clear genotype supported intermediate inheritance of gene expression levels at many genes
10:35-10:50 O-47
Gábor Szabó

Regulation of nucleosome stability: the roles of histone PTMs, histone variant composition and superhelicity
O-53
Melinda Bence

Initiation of Piwi Mediated Heterochromatin Formation in Drosophila Melanogaster
10:50-11:05 O-48
Gyula Timinszky

PARP inhibitors and the molecular mechanisms underlying their PARP1 trapping activity
O-54
Melinda Pirity

Polycomb protein RYBP associates with cardiac transcription factor NKX2-5 to regulate Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells
11:05-11:40 Coffee break
11:40-12:55 Plant Biology & Regulatory RNA
Congress Hall
Chair: László Szabados
Autophagy and i.c. trafficking
Room Liget I.
Chair: Tibor Vellai
11:40-11:55 O-55
László Szabados

Proline metabolism acts as regulatory hub in higher plants
O-60
Tamás Csizmadia

The role of ubiquitin in the secretory granule degradation in Drosophila
11:55-12:10 O-56
Renáta Hamar

The zebrafish snoRNAome
O-61
Endre Kókai

Cathepsin D interacts with the adenosine A2A receptors in mouse macrophages establishing a mutual molecular and functional regulation
12:10-12:25 O-57
Anita Sós-Hegedűs

Molecular Analysis of Tomato Shoestring Symptom
O-62
Sarolta Tóth

Plasmamembrane calcium pump PMCA4b is a new regulator of lumen formation and secretion
12:25-12:40 O-58
Anna Anita Rácz

Small RNA sequencing reveals specific microRNA signatures due to invasive aspergillosis in oncohematology patients
O-63
Gábor Hajdú

Lysosome-related organelles are required for toxic stress-induced cytoprotective and immune responses in C. elegans
12:40-12:55 O-59
Anikó Zeöld

miRNA profiling of extracellular vesicles from pancreatic ductal adenocarcinoma patient-derived organoids and blood
O-64
László Homolya

Theratype-based classification of medically important mutations in the ABCG2 multidrug transporter
13:00-13:15 Closing and award ceremony
Congress Hall
13:15- Lunch

 

List of posters - 5-6 November 2021

P-001Marianna Holczer
The systems biological analysis of PP2A-ULK1-mTORC1 regulatory triangle
P-002Zoltán Kovács
Nuclear import dynamics of the Drosophila moesin protein
P-003Tibor Kovács
Autophagy is required for spermatogonial differentiation in the Drosophila testis
P-004Hussein Abu Ammar
Role of lysoosmal Trpml/mucolipin-1 calcium channel in starvaton-induced autophagy
P-005Asha kiran Maddali
Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila
P-006Dávid Hargitai
Characterization of the endolysosomal SNARE proteins in Drosophila melanogaster
P-007Anna Dósa
The role of E3 ubiquitin ligases in the regulation of crinophagy
P-008Adél Ürmösi
Analyzing the importance the loss of ubiquitinated protein autophagy due to a mutation in Ref(2)P/p62 in Drosophila
P-009Tamás Maruzs
Exploring Sorting nexin functions in Drosophila
P-010Janka Szinyákovics
A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging
P-011Enikő Lakatos
Investigation of the function of Snx21 in Drosophila melanogaster
P-012Gábor Hajdú
LRO-dependent stress and immune defenses require the pgp-2 ABC transporter in C. elegans
P-013Dániel Kovács
Age dependent hormetic response to HSF-1 depletion suggests a compensatory mechanism of cellular stress signaling in Caenorhabditis elegans
P-014Ármin Sőth
Identifying new protein interacting partners of EHD1 in the endosomal system
P-015Zsófia Simon-Vecsei
Investigation of the balance between human endolysosomal tethering complexes
P-016LINA FADEL
Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with Retinoid X Receptor
P-017Márk Kovács
COMPARATIVE TRANSCRIPTOME ANALYSIS OF SACCHAROMONOSPORA AZUREA STRAINS IN TERMS OF PRIMYCIN PRODUCING ABILITY
P-018Walliyulahi Ajibola
Seeking novel antimicrobials derived from environmental bacteria
P-019Erik Seitz
Development of a new, intercellular network model of the epithelial-mesenchymal transition (EMT)
P-020Máté Metzing
Study of the 3D structures of mixed Saccharomyces cerevisiae colonies
P-021János Juhász
FITTING IN-SILICO YEAST COLONY GROWTH MODEL TO EXPERIMENTAL DATA
P-022Bálint Biró
Mitochondrial insertions in the rabbit nuclear genome
P-023János Barna
Prediction of gene function based on Caenorhabditis elegans operons
P-024Nóra Görög
Investigation of cell-cell interactions between industrial wine yeasts
P-025Tünde Gaizer
SYSTEM LEVEL INVESTIGATION OF YEAST CELL-CELL INTERACTIONS
P-026Veronika Törökné Ács
Revealing the role of different amino acid properties in the disordered flanking regions of linear motifs
P-027Áron Bartha
Discriminating malignant and healthy kidney tissues using proteomic and transcriptomic data
P-028Dávid Keresztes
Potential role of ISG15 and androgen receptor contact in enzalutamide resistance of prostate cancer
P-029Patrik Kovács
GLOBAL ANALYSIS OF EXPRESSION OF TRANSPORTERS IN CHONDROGENESIS
P-030Csaba Pongor
Development of High Throughput Methods to Study Yeast Colony Growth
P-031Dalma Müller
Analysis of DNA methylation associated with altered gene expression in colorectal cancer
P-032Borbála Kovács
Network Topological Reorganization of Signaling Networks In the Oncogenesis of Colon Cancer
P-033Ádám Nagy
Transcriptomic effect of APC mutations in colon adenocarcinoma
P-034Péter Fauszt
Investigating the dietary habits- and lifestyle-induced changes in gut microbiota composition and functionality by the application of shotgun next-generation sequencing
P-035Bernadette Hotzi
HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes
P-036Gábor Fidler
Effect of geographical provenance on the antimicrobial resistance load of the human gastrointestinal tract
P-037Bence Keömley-Horváth
Predicting drug side-effects using whole-cell level protein complex simulations
P-038Péter Dávid
Investigation the influence of agronomic management on the vineyard soil, trunk-bark and grape berry microbiome of Vitis vinifera from Tokaj-Wine region and Pallag-Botanical and Exhibitional garden
P-039Márk Kerestély
Boolean modelling of protein translocations reveals compartment-specific perturbations altering the fate of epithelial-mesenchymal transition
P-040János Tibor Fekete
Random forest model to identify predictive genes in colorectal cancer samples
P-041Otília Menyhart
Potential druggable targets in VHL-mutant clear-cell renal cell carcinomas (ccRCC)
P-042Szonja Kovács
Predictive role of MLH1 (MutL Homolog 1) in malignant cancers treated with immunotherapy
P-043András Szabó
Charged residue repeats and their effects on liquid-liquid phase separation
P-044Margita Ágnes Márton
A systems biological analysis of ER stress-induced ATF4-GADD34-CHOP regulatory triangle
P-045Viktor Dombradi
MEMBRANE-FUNCTIONS OF THE FUNGUS SPECIFIC PROTEIN PHOSPHATASE Z1
P-046Renáta Gáspár
Kynurenic acid exerts antiapoptotic effects against simulated ischemia/reperfusion injury on H9c2 cells
P-047Zsuzsa Szondy
TAM KINASE SIGNALING IS INDISPENSABLE FOR PROPER SKELETAL MUSCLE REGENERATION IN MICE
P-048Csaba Matta
SYNCHRONISING THE CIRCADIAN CLOCK WITH MECHANICAL STIMULI DURING IN VITRO CHONDROGENESIS
P-049Enikő Jávor-Hocsák
Regulation of the ATF4-MKP-1-MAPK-mitochondrial damage-cell death pathway by PARP-1 in oxidative stress
P-050Nour Al Zaeed
Impaired Skeletal Muscle Development and Regeneration in Transglutaminase 2 Knockout Mice
P-051Enikő Sutus
Novel blood cell culturing method underlines leukocyte plasticity in Drosophila melanogaster
P-052Dóra Halmi
The role of mitoprotection in the cytoprotective effect of kynurenic acid against simulated ischemia/reoxygenation-induced cardiac cell damage
P-053Aliz Géczi
A machine learning based approach to identify blood cell fates in Drosophila melanogaster
P-054Eliza Guti
The receptor tyrosine kinase inhibitor sunitinib confers resistance to breast carcinoma cells from natural killer cell-mediated ADCC
P-055Isotta Sturniolo
A TUMOR SPHEROID MODEL TO INVESTIGATE THE INTERACTION BETWEEN MACROPHAGES AND CANCER CELLS
P-056Marvi Ghani
Effect of depletion of Drp1 and PA200 on neuronal differentiation and mutant huntingtin (mHtt) aggregate formation
P-057Nastaran Tarban
ROLE OF RETINOL SATURASE ENZYME IN SKELETAL MUSCLE REGENERATION
P-058Kinga Fedor-Lénárt
Tissue transglutaminase knock-out preadipocytes and beige cells of epidydimal fat origin possess decreased mitochondrial functions required for thermogenesis
P-059Mevan Jacksi
The role of Ezh2 and Tks4 in EMT-related processes
P-060Julianna Lilienberg
Pharmacological modulation of neurite outgrowth in human neural progenitor cells by inhibiting non-muscle myosin II
P-061János Sónyák
The role of PMCA4b in mammosphere formation and secretion in 3D cell cultures of MCF7 cells
P-062Alexandra Brigitta Szarka-Kovács
Mesr4: A novel positive regulator of germline differentiation
P-063Abhirup Shaw
BMP7 upregulates both UCP1 dependent and independent thermogenesis in human neck area derived adipocytes
P-064Ákos Bordás
Optimization of non-dividing cell selection in induced pluripotent stem cell-derived hepatic culture
P-065László Sós
Palmitate inhibits efferocytosis by activating the mTORc1/RhoA/Rho kinase pathway
P-066Éva Péntek-Garabuczi
NURR77 INHIBITS PHAGOCYTOSIS OF APOPTOTIC CELLS BY DOWNREGULATING PPARg
P-067Éva Vincze-Fige
RETINOIDS PROMOTE MACROPHAGE DIFFERENTIATION AND EFFEROCYTOSIS BY UPREGULATING BMP-2
P-068Viktória Zsiros
Molecular control of mesenchymal-epithelial transformation after inflammation in mesothelial cells: the role of autophagy and BMP factors in the process
P-069Virginia Varga
Hemocytes influence cellular processes during the regeneration of germline cells in Drosophila testis
P-070Péter Tóth
CHIMERIC ANTIGEN RECEPTOR EXPRESSING MACROPHAGE CELLS (CAR-M) FOR THE THERAPY OF HER2+ SOLID TUMORS
P-071Bianka Csaholczi
Development and characterisation of a transglutaminase 2 knocked down endothelial cell model
P-072Péter Görög
FLIGHTLESS-I REGULATES SARCOMERE GROWTH BY PROMOTING ACTIN ASSEMBLY
P-073Viktor Vedelek
Mitochondrial dynamics and metabolic remodelling in Drosophila spermatogenesis
P-074Bayan Kharrat
HEADCASE AS A PLAYER IN STRESS RESPONSE IN THE HEMATOPOIETIC NICHE IN DROSOPHILA MELANOGASTER
P-075Dávid Farkas
SALS as a novel regulatory factor of sarcomeric growth
P-076Krisztina Tóth
THE ROLE OF FORMINS DURING DROSOPHILA EMBRYONIC DORSAL CLOSURE
P-077Rita Gombos
Drosophila Frl and Enabled work together to form actin cables for positioning nuclei during oogenesis
P-078Roland Ádám Takács
Identification of possible novel transcription factors during chondrogenic differentiation
P-079László Henn
How does the alternative linker histone ensure the earliest developmental steps in Drosophila?
P-080Lili Adorján
Emerging new role of RYBP and lncRNA Paupar in regulating Pax6 during neural differentiation
P-081Zsanett Takács
Analysis of a novel heterochromatin regulator in Drosophila Melanogaster
P-082Lilla Kókity
Mouse RYBP is important for cardiac mesoderm and progenitor formation in vitro
P-083Latifa Kazzazy
Uracil in the DNA during the early development of zebrafish
P-084Eszter Németh
Prospectively-defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
P-085Vasiliki Pantazi
Ubiquitylation mediated transcription regulation upon DSB induction
P-086Hasan Mamar
The loss of the DNA polymerase epsilon subunits POLE3 and POLE4 results in PARP inhibitor sensitivity
P-087János Pálinkás
Pathways of D-loop processing by human Bloom’s syndrome helicase are markedly influenced by the Toposiomerase IIIalpha-RMI1-RMI2 complex
P-088Gábor Papp
Correlation between uracilation and transcriptional changes in drug treated HCT116 colon cancer cells.
P-089Eszter Holub
Induced C to T transition mutations in anticancer drug treated HCT116 cells
P-090Angéla Békési
Getting mechanistic insight into the action of thymidylate synthase inhibitory drugs
P-091Szilvia Juhász
The effect of G4 stabilization on genome integrity
P-092Zita Bognár
Desethylamiodarone may have cytostatic potential on triple negative breast cancer
P-093Vikas Patel
MOLECULAR ALTERATIONS ASSOCIATED WITH BRAFi/MEKi RESISTANCE IN MELANOMA CELL LINES
P-094Stephanya Corral
Identification of Microorganisms of Biotechnological Importance and their Characterization by Microbiological and Molecular Biological Approaches
P-095Orsolya Ungvári
A competitive counterflow assay to distinguish between substrates and inhibitors of the hepatic drug transporter OATP1B1
P-096Balázs Gombos
Application of a transgenic mouse model for chemotherapy optimization
P-097Eszter Bajtai
CHARACTERIZATION OF CHEMOTHERAPY-SURVIVING TUMOR CELLS AND UNDERSTANDING THEIR ROLE IN RELAPSE
P-098Nikoletta Murvai
STUDY OF INHIBITION OF ALZHEIMER’S AMYLIOD-Β PEPTIDE AGGREGATION AND TOXICITY
P-099Thu Hien Vu
Biocides are unlikely to be a major source of antibiotic resistance
P-100Rosevalentine Bosire
ACCESSIBILITY OF DNA IN CHROMATIN: THE INFLUENCE OF CONSTRAINED SUPERHELICITY
P-101Harem Muhamad Amin
The RBR-polyQ Region Of KMT2D Enzyme: Unique Sequence-Specific Function
P-102Ranti Dev Shukla
inPOSE: an IS3 element-mediated and CRISPR/Cas9-assisted robust synthetic biology tool for transgene integration and amplification in bacterial genomes
P-103Orsolya Mózner
Examining the modulation of the plasma membrane calcium pump PMCA4b in erythroid cells
P-104Márton Miskei
Genome-wide mapping of SETMAR transposase binding sites in the human genome
P-105Judit Vágó
MODULATION OF DNA METHYLATION INFLUENCES CARTILAGE FORMATION IN MURINE CHONDROGENIC MODELS
P-106Ferenc Jankovics
Drosophila small ovary gene is required for transposon silencing and heterochromatin organization
P-107Viola Varga
The epigenetic role of ascorbate in the pathomechanism of arterial tortuosity syndrome
P-108Ákos Avramucz
Towards a T7/K1F chimera phage
P-109Noémi Borbély
Towards building the genetic map of the Carpathian Basin
P-110Erzsébet Fóthi
Similar or a little different? Two Hungarian-speaking populations in the Hungarian-Slavic contact zone
P-111Dorottya Simon
PEAR: a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells
P-112Tímea Pintér
INVESTIGATION OF DYSREGULATION OF GABA-GLUTAMATE SYSTEM IN DIP2C KNOCKOUT MOUSE MODEL
P-113Henriett Halász
Studying the role of the microtubules in the formation and function of the membrane nanotubes of B-lymphocytes
P-114Éva Katona
INVESTIGATION OF THE CIRCADIAN CLOCK GENES IN HUMAN MELANOMA CELLS
P-115Ádám Diós
Optimization of biosensor utilization for celiac disease related antibody quantification in BLItz system
P-116András Áron Soós
Wnt secretion is uncoupled from cell proliferation and extracellular vesicle release in human pancreatic ductal adenocarcinoma organoids
P-117Loretta László
Significance of Tks4 scaffold protein in embryonic stem cell differentiation: First steps in establishment of a new Tks4-KO HUES9 cells
P-118Tamás Fehér
Investigating a female-limited progressive myopia disease in a Hungarian family
P-119Edit Szabó
Potential diagnostic role of red blood cell membrane proteins in type 2 diabetes
P-120Anna Kulin
Investigation of factors behind the expression pattern of the GLUT1 membrane protein – potential relevance in diabetes
P-121Ádám Ungvári
Progesterone-dependent transcriptional programming provides smoothelin-like 1 reversal of insulin resistance in myotubes and mice
P-122Zsófia Ruppert
Sex-dependent effects of high-fat diet and HSPB1 overexpression in a mouse model of hyperlipidemia
P-123Melinda Tóth
Beneficial effects of regular exercise training on metabolic disturbances in ApoB100-overexpressing transgenic mice: sex-specific responses
P-124Szilvia Blénesi
The fear of hunger: starvation-induced aversive associative memory in C. elegans
P-125Mihály Székely
Protein arginine methyltransferase 5 in the pathomechanism of human lung cancer
P-126Zsófia Nagy
Investigation of the expression of dual oxidases in the gastrointestinal tract of cattle suffering from Left-Sided Displacement of the Abomasum
P-127Brigitta Dukay
Sex-dependent effects of regular exercise on cognitive function in healthy and hyperlipidemic mice
P-128Rini Arianti
ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation
P-129Boglárka Ágnes Vinnai
Long-Term Thiamine Treatment Elevates Thermogenic Competency of Human Adipocytes
P-130Ilka Keller
The role of SMTNL-1 in the physiological and pathological functions of the female reproductive system
P-131Vince Szegeczki
Alterations of mRNA expression in PACAP treated in vitro ectopic endometrial tissues
P-132Attila Vámos
SYSTEMATIC ANALYSIS OF BEIGE TO WHITE TRANSITION OF HUMAN PRIMARY ADIPOCYTES
P-133Diána Kaszás
PMCA4b contributes to lumen formation and transcellular trafficking in the breast cancer MCF7 cell line
P-134Gyöngyi Munkácsy
PREDICTIVE ROLE OF MKI-67 AND PCNA CELL PROLIFERATION MARKERS IN THE PHARMACOLOGICAL TREATMENT OF BREAST CANCER
P-135Réka Nagy
Arf6 mediates endocytosis of PMCA4b in HEK cells
P-136Tamás Juhász
PAC1 receptor expression in aging of cartilage in human knee joints
P-137Dávid Kis
TYPES OF LEUKAEMIA IN RADIATION AND EXTRACELLULAR VESICLES INDUCED LEUKEMOGENESIS
P-138Katalin Balázs
Radiotherapy-induced changes in systemic immune parameters of prostate cancer patients
P-139Péter Pikó
The Profile of HDL-C Subfractions and Their Association with Cardiovascular Risk in the Hungarian General and Roma Population
P-140István Szász
Liquid biopsy-based biomarker identification in colorectal cancer
P-141Dóra Csige
Investigation of the conformational epitope of mouse monoclonal antibody 885 recognizing a celiac-related surface in transglutaminase 2
P-142Krisztina Köröskényi
Loss of adenosine A3 signalling protects mice against diet-induced obesity
P-143Tamás Molnár
DISEASE RELATED D76N MUTATION OF Β2-MICROGLOBULIN: SYNERGY OF ADVERSE EFFECTS BOTH ON THE NATIVE AND AMYLOID STATES
P-144Krisztina Jámbor
Investigating osteopontin - a possible biomarker - in malignant melanoma cell lines in two levels
P-145Francesco Desiderio
Prunus virus F is present in Hungarian sour cherries
P-146Evans Duah Agyemang
Symptom on Clematis vitalba could be a reason for an infection with Prunus virus I
P-147Roland Gábor Vékony
INVESTIGATION OF THE ROLE OF THE NEUROPEPTIDE PACAP IN THE REGULATION OF THE CYTOSKELETAL SYSTEM
P-148Gerda Wachtl
Roles of the N-terminal Disordered Protein Region in PiggyBac transposition
P-149Brigitta Maruzs
NMR characterisation of the EVH1 domain of the postsynaptic Homer1 protein
P-150Bálint Péterfia
Natural point mutations of the PDZ domain affect ligand binding of the postsynaptic Shank1 protein
P-151Balint Nagy
Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure
P-152Eszter Nagy-Kanta
NMR-based structural characterization of the post-synaptic density scaffold protein GKAP
P-153Patrik Horváth
In vitro interaction studies of chlorotoxin and its tumor-associated partners
P-154András Czajlik
Structural and Dynamical Investigation of Shank-1 PDZ domain
P-155Péter Ecsédi
Utilization of annexin A2 as a crystallization chaperon
P-156Fanni Farkas
Interaction and atomic level investigation of GBR region of GKAP and GK domain of PSD-95
P-157Beáta Bugyi
Structural - Functional Analyses of the Gelsolin Homology Domains of Flightless-I in Actin Dynamics
P-158Rawan Abukhairan
RNA regulated phase Separation of KMT2D
P-159Krisztina Veszelyi
REDOX HOMEOSTASIS OF THE ENDOPLASMIC RETICULUM – ABSENT ELECTRON TRANSFER CHAINS IN THE LUMEN?
P-160Beáta Szabó
Disease causing mutations of KMT2D RNA binding domain affect its phase separation
P-161Éva Schád
Relationship between interfaces, binding strength and specificity of disordered protein complexes
P-162Zsuzsánna Réthi-Nagy
A NOVEL PROTEIN TAG FOR IMMUNODETECTION AND AFFINITY PURIFICATION OF PROTEINS
P-163András Micsonai
BeStSel: protein secondary structure estimation and fold recognition from CD spectra
P-164Gergő Kalló
Reduced level of tear antimicrobial and immunomodulatory proteins as a possible reason for higher ocular infections in diabetic patients
P-165Erdenetsetseg Nokhoijav
Complex examination of body fluids in diabetes and obesity
P-166Andrea Guba
Method development for simultaneous analysis of 33 amino acid and biogenic amine from serum and tears
P-167Zsuzsa Csobán-Szabó
An attempt to reveal the biological function of human transglutaminase 4 in the intestinal tract
P-168Tibor Hajdú
DISSECTING THE SURFACE: PROTEOMIC ANALYSIS OF THE SURFACEOME IN HUMAN PIGMENT CELLS
P-169Éva Klement
ION MOBILITY FOR IN-DEPTH PROTEOMICS OF COMPLEX BIOLOGICAL SAMPLES
P-170Barbara Borsos
Monitoring breast cancer-related qPCR-based miRNA profile
P-171Luca Gál
Regulation of alternative splicing in connection with intronic miRNA maturation pathways
P-172Ilona Csordás
Ionizing radiation effect on the miRNA cargo of extracellular vesicles
P-173Anita Schamberger
Examination of artificial mirtrons designed to silence the ABCG2 multidrug transporter protein
P-174Zsuzsanna Biczók
Allele-specific editing of stem cell models carrying autosomal dominant mutations using the CRISPR/Cas system
P-175Anshu Sharma
EFFECT OF DOXORUBICIN ON RAR MOBILITY AND CHROMATIN BINDING
P-176Chinzorig Jeppesen
EGF BINDING TO ITS RECEPTOR OCCURS ALREADY IN THE GOLGI
P-177Boglárka Bozsó
Intracellular ligand binding of the IL-2 receptor
P-178Tamás Maruzs
Exploring Sorting nexin functions in Drosophila
P-179Bálint Biró
Mitochondrial insertions in the rabbit nuclear genome
P-180Zsuzsa Szondy
TAM KINASE SIGNALING IS INDISPENSABLE FOR PROPER SKELETAL MUSCLE REGENERATION IN MICE
P-181Kinga Fedor-Lénárt
Tissue transglutaminase knock-out preadipocytes and beige cells of epidydimal fat origin possess decreased mitochondrial functions required for thermogenesis
P-182Abhirup Shaw
BMP7 upregulates both UCP1 dependent and independent thermogenesis in human neck area derived adipocytes
P-183Eszter Németh
Prospectively-defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
P-184Angéla Békési
Getting mechanistic insight into the action of thymidylate synthase inhibitory drugs
P-185Rosevalentine Bosire
ACCESSIBILITY OF DNA IN CHROMATIN: THE INFLUENCE OF CONSTRAINED SUPERHELICITY
P-186Ferenc Jankovics
Drosophila small ovary gene is required for transposon silencing and heterochromatin organization
P-187Noémi Borbély
Towards building the genetic map of the Carpathian Basin
P-188Rini Arianti
ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation
P-189Beáta B. Tóth
Regulatory Modules of Human Thermogenic Adipocytes: Functional Genomics of Large Cohort and Meta-Analysis Derived Marker-Genes
P-190Bálint Péterfia
Natural point mutations of the PDZ domain affect ligand binding of the postsynaptic Shank1 protein
P-191Flóra Szeri
Plasma inorganic pyrophosphate level decreases in pregnancy resulting in elevated Cardiovascular Disease Risk in women giving multiple childbirths